PhD student in Molecular Toxicology

The Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences in Basel (Switzerland), is offering a PhD position to investigate chemicals altering steroid biosynthesis.

Your position

The project is funded by the Swiss Centre for Applied Human Toxicology (SCAHT). This interdisciplinary research project is a collaboration with four partner institutions and focuses on investigating disruptions of steroidogenesis induced by endocrine-disrupting chemicals (EDCs). EDCs are exogenous substances or mixtures interfering with hormone receptors and signalling pathways or altering hormone synthesis, transport, and metabolism, ultimately leading to adverse health effects. Steroid hormone producing glands such as the adrenals, ovaries and testes are particularly susceptible to EDCs due to their highly vascularized, lipid-rich environment necessary for steroid biosynthesis, and the presence of cytochrome P450 enzymes that produce free radicals and reactive intermediates. These properties make steroidogenesis a critical target for chemical-induced endocrine disruption. By disturbing steroid biosynthesis EDCs are posing risks for metabolic, immune, neuronal and long-term reproductive diseases in both males and females. While compounds such as phthalates and bisphenol A (BPA) have been well studied, there is limited knowledge about the endocrine-disrupting potential of their newer derivatives and replacement chemicals. Addressing this knowledge gap is essential for identifying potential hazards posed by such emerging substances. The goal of this project is to assess the impact of phthalates, bisphenols, and more importantly their analogues on steroid hormone biosynthesis in adrenal, testicular, and ovarian systems. The study will primarily employ in vitro cell-based assays to evaluate these effects. Depending on activity and relevance from the literature, the most promising active compound(s) may be further investigated in animals.
We are seeking a motivated and enthusiastic individual with basic experience in cell culture and biochemical/molecular biology techniques. The ideal candidate is a collaborative team player with a strong interest in toxicology and endocrine research. We offer a dynamic, diverse, and international research environment with access to state-of-the-art facilities and a supportive team culture. The project offers an excellent opportunity for scientific development in the field of endocrine toxicology. The position is located in Basel, an international city with people from various nations. Located on the border where three countries meet (Switzerland-Germany-France), Basel is a very lively city with an excellent scientific, recreational, and cultural environment.

Your profile

• MSc degree in molecular life sciences
• Skills in molecular biology, cell biology, biochemistry, and cell culture
• Basic knowledge in physiology is beneficial but not mandatory
• Excellent communication in spoken and written English (ideally good knowledge in German and French but not mandatory)
• Highly motivated
• Ability to work independently and as a part of a research team

We offer you

• PhD position aiming for a PhD degree at the University of Basel, Switzerland
• International research environment
• Training into the key techniques
• Participation in the PhD program for Pharmaceutical Sciences
• Integration into the Swiss Centre for Applied Human Toxicology network