MISSION
Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously.
POSITION SUMMARY
The Vice President of International Medical Affairs (VP IMA) will serve as the senior medical leader responsible for shaping and executing global medical affairs strategy outside the U.S. for the company’s portfolio in rare, cholestatic liver diseases, including Alagille syndrome (ALGS), Progressive Familial Intrahepatic Cholestasis (PFIC), Primary Sclerosing Cholangitis (PSC), and Primary Biliary Cholangitis (PBC) along with other assets in the pipeline.
This executive will drive medical and scientific excellence across regions, ensuring patients, healthcare professionals, and policymakers have timely, accurate, and impactful access to data and education. The role emphasizes patient-centricity, cross-functional partnership, and the advancement of innovative therapies that address high unmet needs in rare liver diseases.
JOB FUNCTIONS/RESPONSIBILITIES
Strategic Leadership in Rare Disease
- Define and lead international medical affairs strategy for rare cholestatic liver disorders, ensuring alignment with global R&D, regulatory, and commercial priorities.
- Anticipate and address unique challenges in rare disease access, patient identification, diagnosis, and treatment adoption across diverse healthcare systems.
- Guide strategy for clinical and real-world evidence to fill knowledge gaps in small, underserved patient populations.
Scientific Engagement
- Build strong scientific and clinical partnerships with hepatologists, pediatric liver specialists, gastroenterologists, and key opinion leaders (KOLs) in rare liver diseases.
- Partner closely with patient advocacy groups (PAGs) to ensure the patient and caregiver perspective informs all programs.
- Lead the development of specialized scientific education tailored to rare disease communities, ensuring accuracy, cultural sensitivity, and accessibility.
Evidence Generation & Data Dissemination
- Shape the medical affairs evidence strategy in international medical affairs to address critical unmet needs in Alagille syndrome, PFIC, PSC, and PBC.
- Align with Executive Director, Scientific Affairs on sponsored studies, real-world evidence generation, and investigator-initiated trials designed to expand understanding of these rare disorders.
- Ensure rapid, compliant dissemination of clinical trial and real-world data across international regions—through collaboration with publications team.
Cross-Functional Collaboration
- Partner with clinical development to provide insights on trial design that address practical challenges in rare disease recruitment, endpoints, and regulatory expectations.
- Collaborate with Market Access and HEOR to build compelling value narratives for rare disease therapies, addressing challenges in cost-effectiveness and reimbursement.
- Support global and regional commercial brand teams in preparation for new product launches and lifecycle management in rare cholestatic liver diseases.
Governance & Compliance
- Ensure all rare disease medical activities comply with international and local regulations, rare disease frameworks, and ethical standards.
- Uphold transparent, patient-first approaches in all communications and engagements.
Team Leadership
- Build and lead a high-performing international medical affairs team with deep expertise in rare diseases and hepatology.
- Mentor and develop medical affairs professionals to become future leaders in rare disease medicine.
- Foster a culture of transparency, innovation, agility, and scientific rigor.
QUALIFICATIONS
- Advanced degree (MD, PhD, or PharmD) required; hepatology, gastroenterology, or pediatrics specialization preferred.
- Minimum 15 years of experience in biopharma with 10+ years in medical affairs leadership.
- Demonstrated expertise in rare disease strategy, ideally within hepatology, gastroenterology, or metabolic disorders.
- Experience with orphan drug development, rare disease regulatory pathways, and global health authority interactions.
- Proven track record in rare disease product launches, KOL engagement, and patient advocacy partnerships.
- Deep understanding of payer and access challenges unique to rare disease therapies.
- Exceptional leadership, intercultural collaboration, and scientific communication skills.
Personal Attributes
- Patients are our North Star: Deep commitment to improving the lives of patients and families affected by rare liver disease.
- Strategic Agility: Ability to navigate uncertainty, evolving science, and small data sets.
- Collaborative Influence: Builds trust and alignment across scientific, regulatory, and commercial stakeholders.
- Cultural Competence: Sensitivity to the needs of diverse patient populations and healthcare systems worldwide and adheres to Mirum corporate values.
- Integrity & Credibility: Recognized as a trusted leader by both internal colleagues and external medical communities.
- Expert Communicator: Ability to give medical and scientific presentations to a diverse audience, tailoring talking points appropriately.
- Highly Organized: Possess the ability to work on multiple competing projects and manage to deadlines.
- Technologic skills: Microsoft PowerPoint, Excel, TEAMs, OneNote, ChatGPT (internal)
Mirum Pharmaceuticals is committed to Equal Employment Opportunity (EEO) and to compliance with all Federal, State and Local laws that prohibit employment discrimination on the basis of race, age, national origin, ethnicity, religion, gender, gender identity, pregnancy, marital status, sexual orientation, citizenship, genetic disposition or characteristics, disability, veteran’s status or any other classification protected by applicable State/Federal/Local laws.
Mirum Pharmaceuticals provides reasonable accommodation for qualified individuals with disabilities and disabled veterans in job application procedures.
