Bioinformatician / Computational Biologist 100%

The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated Bioinformatician / Computational Biologist to analyse single cell genomics data, with a focus on the molecular mechanisms of myopia.

IOB is a research institute associated with the University of Basel which combines basic and clinical research. Its mission is to drive innovations in understanding vision and its diseases and develop new therapies for vision loss.

Due to myopia’s rising prevalence, it will become the leading cause of blindness worldwide, constituting one of the most significant public health challenges of our time. IOB uses state of the art single cell genomics and epigenomics techniques to advance the mechanistic understanding of myopia at the level of cell types and molecular pathways, and to test new therapies designed to halt or reverse myopia progression. In your role, you will utilise your expertise to collaborate with a multidisciplinary international team and contribute towards major breakthroughs in Human Medicine.

• Analyse diverse -omics datasets, including single cell RNA-seq, ATAC-seq and proteomics
• Create cell type atlases and leverage them to answer biological research questions
• Support tissue engineering and therapeutic efforts by characterising intra/intercellular signalling pathways
• Compare diseased cell types to their healthy normal counterparts
• Organise sequencing data and maintain metadata information
• Participate in the development of pipelines to automate commonly used workflows
• Communicate clearly with biologists and bioinformaticians to identify objectives and convey results

• PhD in bioinformatics, computational biology or a related quantitative discipline
• Minimum 3 years of experience in next-generation sequencing data analysis, preferably including multiomics single cell data
• Experience in the analysis of spatial transcriptomic data is a plus
• Competence in Python, R and Unix/Linux is required. Experience with workflow management (Snakemake or Nextflow) and high performance or cloud computing is desirable
• In-depth knowledge of common sequencing technologies
• Experience deciphering intra- and intercellular signalling pathways is desirable
• Excellent written and verbal communication skills in English

• Highly competitive conditions in a dynamic and international research community in Basel
• Five weeks of vacation for all employees, with increasing amount of vacation days by age
• IOB is an equal-opportunity employer with family-friendly work policies. We offer a childcare subsidy and family room, among other forms of support
• Opportunities for professional growth and development, including support for additional training and education
• The chance to be part of a groundbreaking research institute. At IOB, your work will be highly meaningful for society, your expertise will be valued, and your abilities will be challenged

Application / Contact

Interested candidates should submit their application documents through our online recruitment platform. Please include a personal statement, your Curriculum Vitae, as well as relevant certificates/diplomas.